Floyd Mayweather Jr vs Shane Mosley LIMITED EDITION MGM Grand room key billed, "Who R U Picking?" 1st May, 2010, MGM Grand, Las Vegas.

Condition mint

Mayweather W unanimous decision
The opening round saw both superbly quick handed fighters come out tentatively each looking to counter the other. Apart from a few decent jabs, neither fighter landing to effect. Mosley went down midway through the round from a slip. A pair of big right hands hurt Mayweather in the 2nd and it appeared at one point that he may go down. He was able to maintain himself, however, until the end of the round. Mayweather appeared to have regained his composure and likely won the 3rd Round by stepping up his aggression and pressing Mosley. Round 4 again was a very measured round, with both fighters looking to land big counter-right hands. Apart from some nice jabs, though, the major punch of the round was a right hand by Mayweather. The 5th Round saw both fighters winging with often wild shots, but neither landing noticeably more so or more effectively than the other. In the 6th, both fighters looked to feint and counter, but Mayweather appeared to have made the better changes and was a step ahead. Round 7 and 8 expanded the gap between the two fighters as Mayweather landed cleanly against a determined but a slowed Mosley. It was evident that Mayweather was in his zone and beginning to cruise. In the 9th, Mosley was the busier of the two but Mayweather continued to land more effectively and battered his opponent with right hands. Mayweather continued to pound Mosley in the 10th and hurt him with a digging body shot. Following the round, Mosley's corner hinted at stopping the fight if he didn't show them something. The 11th saw a game Mosley throw punches but not be able to land against Mayweather's philly shell. Floyd continued to snap Mosley's head back with jabs and right hands. The final round continued much as the several previous. Mosley threw but was out of gas and Mayweather picked his spots with straight shots.

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Floyd Joy Mayweather, Jr. (born Floyd Sinclair on February 24, 1977). He is undefeated as a professional, with a record of 41–0 (25 KOs). He is the son of Floyd Mayweather, Sr., a former welterweight boxing contender.
From July 18, 2005 through June 2, 2008 he was rated by The Ring magazine as the number-one pound for pound boxer in the world. Mayweather has won six world boxing championships in five different weight classes; he is the former WBC welterweight champion, a title he vacated upon his retirement. He was named Ring Magazine Fighter of the Year in 1998 and 2007. ESPN.com listed Mayweather at #48 on their "50 Greatest Boxers of All Time" list.

Background
Floyd Mayweather Jr. was born in Grand Rapids, Michigan, with his mother's last name. His last name would change to Mayweather shortly thereafter. His father, Floyd Mayweather, Sr., is a former welterweight contender, while two of his uncles, Jeff Mayweather and Roger Mayweather, won championship titles.

Amateur Career
Before Mayweather had a successful amateur career of 84-6 he was raised in his home town. He won national Golden Gloves championships in 1993 (at 106 lb), 1994 (at 114 lb), and 1996 (at 125 lb). He was given the nickname "Pretty Boy" by his amateur teammates because he had relatively few scars, a result of the defensive techniques that his father (Floyd Mayweather, Sr.) and uncle (Roger Mayweather) had taught him. In his orthodox defensive stance, Mayweather—much like James Toney—often utilizes the 'shoulder roll'. The shoulder roll is an old-school boxing technique in which the right hand is held normally or slightly higher than normal, the left hand is down around the midsection, and the lead shoulder is raised high on the cheek in order to cover the chin and block punches. The right hand (from orthodox stance) is used as it normally would be to block punches coming from the other side, such as left hooks. From this stance, Mayweather blocks, slips, and deflects most of his opponents' punches, even when cornered, by twisting left and right to the rhythm of their punches.

At the 1996 Olympics in Atlanta, Mayweather won a bronze medal by reaching the finals of the featherweight (57 kg) division's 31-boxer tournament. In the opening round, Mayweather led 10-1 on points over Bakhtiyar Tileganov of Kazakhstan before he won by round 2 referee stoppage. In the second round, Mayweather outpointed Artur Gevorgyan of Armenia 16-3. In the quarterfinals, Mayweather survived a late rally by Lorenzo Aragon of Cuba to win 12-11. In his semifinal bout against the eventual silver medalist, Serafim Todorov of Bulgaria, Mayweather lost by a controversial decision that the U.S. team officially protested. Many who saw the bout, including the referee (who mistakenly raised Mayweather's hand when the decision was read), believed that Mayweather had won.

Professional Career - Super Featherweight
Mayweather fought his first professional bout on October 11, 1996 against fellow newcomer Roberto Apodaca. Apodaca was knocked out in round 2. Mayweather's trainer at the time was his uncle, Roger Mayweather, because Floyd Mayweather, Sr. was still imprisoned after having been convicted of illegal drug trafficking in 1993. Mayweather, Sr. took over as Mayweather, Jr.'s trainer when he was released from prison (after Mayweather, Jr.'s fourteenth fight—a second-round knockout of Sam Girard). From 1996 to early 1998, Mayweather won most of his fights by knockout or TKO.

In 1999, Mayweather won his first world title, the WBC junior lightweight (130 lb) championship, when the corner of Genaro Hernandez stopped the fight after round 8. Hernandez had never been defeated at the weight class. From there, Mayweather defended his title with performances against contenders such as Angel Manfredy and Carlos Gerena.

Before he fought against former WBC featherweight champion Gregorio Vargas in early 2000, Mayweather fired his father as his manager and replaced him with James Prince. A few months after the fight, the rift between the father and son became wide enough that Mayweather, Jr. fired Mayweather, Sr. as his trainer as well. Roger Mayweather returned to his role as Mayweather, Jr.'s trainer in his next bout—a non-title fight against Emanuel Burton. In an interview in 2004, Mayweather, Jr. said that he loves Mayweather, Sr. as his father but feels that he has better chemistry with Roger, and his father had put too much pressure on him to be perfect.

Mayweather's biggest fight as a junior lightweight was on January 20, 2001, against Diego Corrales. At the time, neither fighter had been defeated or knocked down. In the bout, Mayweather won every round and knocked down Corrales five times (three times in round 7 and twice in round 10). After the fifth knockdown, Corrales' cornermen climbed onto the apron and stopped the fight, thereby establishing Mayweather as one of the claimants to boxing's mythical pound-for-pound title. At the time of the stoppage, Mayweather was way ahead on the scorecards, leading by the official tallies of 89-79, 90-79, and 90-78.
In Mayweather's next bout, on May 26, 2001, future IBF champion Carlos "Famoso" Hernández knocked down Mayweather for the first time. Mayweather entered the bout with injured hands. When Mayweather hit Hernández with a left hook in round 6, the pain caused Mayweather to drop his left hand to the canvas, and the referee called it a knockdown. Nonetheless, Mayweather won the fight by unanimous decision. In the award-winning documentary film More Than Famous, Hernández's bout against Mayweather was prominently featured.

Mayweather's last fight in the junior lightweight division was against future junior lightweight and lightweight champion Jesús Chávez. It was Mayweather's eighth defence of the WBC junior lightweight title, which he had held for more than three years. He won when Chávez's corner stopped the fight after round 9. Mayweather had such difficulty making weight for this fight that he did not eat for four days before the weigh-in.

Lightweight
In 2002, Mayweather moved up to the lightweight (135 lb) division. Mayweather fought only four bouts at this weight, but they were all world championship fights. Mayweather won two bouts for the WBC and The Ring lightweight belts against José Luis Castillo. In their first bout, Castillo had success when he cut off the ring and used his strength to wear down Mayweather. But it was not enough to make up for his slow start in the fight. Still, many analysts and fans feel that Mayweather should have lost the fight, but he won by unanimous decision. In the rematch, Mayweather used his quick footwork and combinations to coast to another unanimous decision victory, this time with no controversy. The smaller Mayweather was outweighed by Castillo on the night of the fight, as Castillo weighed 147 and Mayweather weighed 138.

On April 19, 2003, Mayweather dominated the Dominican Victoriano Sosa and won by unanimous decision. Mayweather's next fight (on November 1, 2003) was in his hometown of Grand Rapids, Michigan. He fought against the promising South African knockout specialist Phillip Ndou, whose record was 31-1 with 30 KOs. Uncharacteristically, Mayweather was offensively oriented from the beginning of the fight. Round 5 was one of 2003's most action-packed. In the middle of the round, Mayweather landed a barrage of powerful punches. Ndou endured and threw wild punches that forced Mayweather into the ropes, but Mayweather demonstrated his rhythmic defensive technique and let Ndou wear himself out further. In round 6, Ndou wobbled and was pushed down. In round 7, a combination of three straight right hands knocked down Ndou and caused a TKO, when N'Dou's trainers - Nick Durandt and Tommy Brooks - contemplated throwing in the towel. However, the ref stopped the fight as Ndou did not move forward (as part of a test to ensure he was okay from the knockdown).

Junior Welterweight
Mayweather then moved up to the junior welterweight (140 lb) division. His first fight in this division was against southpaw DeMarcus Corley. Mayweather used his speed to win the early rounds. In the first minute of round 4, Corley landed a solid left hand and drove Mayweather into the ropes, but Mayweather recovered and fought back ferociously. After that round, Mayweather mostly controlled Corley. Mayweather knocked down Corley in rounds 8 and 10, but Corley was able to continue until the end. Mayweather won by unanimous decision. The fight was Mayweather's only one in 2004.

On January 22, 2005, Mayweather fought against Henry Bruseles of Puerto Rico in a WBC junior welterweight title eliminator bout. Mayweather easily outclassed Bruseles throughout the first seven rounds. In round 8, Mayweather knocked down Bruseles twice, and the fight was stopped.

The win over Bruseles made Mayweather the mandatory challenger for Arturo Gatti's WBC Super Lightweight Championship. Before the fight, Mayweather was supremely confident. He described Gatti with terms such as "a C+ fighter", "a fake", and "a blown-up club fighter." The pay-per-view fight occurred on June 25, 2005 in Atlantic City, New Jersey, where the fans heavily supported Gatti. Near the end of round 1, Mayweather pushed Gatti's head down in close and the referee instructed the fighters to "Stop punching." Gatti broke and left himself vulnerable while Mayweather either deliberately or indeliberately disobeyed the referee's command and continued to land punches. Gatti turned to the referee to complain and Mayweather capitalised, sending Gatti to the canvas with more shots for what was scored a knockdown, despite Gatti's complaints. Throughout the next five rounds, the much faster Mayweather landed with nearly every big shot against Gatti, who had no offense with which he could return fire. Gatti's corner stopped the fight after round 6—giving Mayweather his third world title. It was one of the most one-sided and most impressive boxing clinics in boxing history. In the post-fight interview, Mayweather praised Gatti and claimed that his pre-fight comments "were just to sell tickets." Among many boxing experts, Mayweather's one-sided dominance over Gatti solidified his position as the best pound-for-pound fighter in the world. Compubox had Mayweather outlanding Gatti by a total of 168 to 41.

One month after the Gatti clinic, Mayweather went to trial for a domestic violence charge. He faced a minimum of one year in prison if he was convicted. Mayweather had been accused of violence against his former girlfriend, Josie Harris. Harris had claimed that Mayweather had punched and kicked her during an argument in Mayweather's Bentley, outside a Las Vegas nightclub in 2003. During the trial, however, Harris admitted that she had lied on the initial police report and testified that Mayweather never hit her. The jury acquitted Mayweather.

Welterweight
On November 19, 2005, Mayweather fought a non-title bout at 147 lb (67 kg) against welterweight Sharmba Mitchell. In round 3, Mayweather knocked down Mitchell with a straight right hand to the head. In round 6, another straight right hand—this one to Mitchell's body—dropped Mitchell again and ended the fight.

Floyd Mayweather, Jr. vs. Zab Judah
On April 8, 2006, Mayweather defeated Zab Judah for the IBF and vacant IBO world welterweight titles by unanimous decision. Beforehand, the fight had been jeopardized after Judah lost the WBA, WBC and Ring Magazine welterweight titles to Carlos Manuel Baldomir on January 7, 2006, but Mayweather's and Judah's camps reworked the contract and decided that the fight would go on. In the fight, Mayweather stayed calm during Judah's aggressive early rounds. Mayweather began to dominate Judah in round 5, and Judah eventually bled. Near the conclusion of the tenth round, Judah hit Mayweather with a left hand that was clearly below the belt and followed up with a right-handed rabbit punch. After referee Richard Steele called time with five seconds remaining in the round, Roger Mayweather entered the ring and approached Judah, but Steele restrained him. Judah's father and trainer, Yoel Judah, entered the ring as well. Floyd remained in the neutral corner while both Yoel and Zab scuffled with Roger (and others who had entered the ring) until police and security managed to restore order. Roger was thrown out, but the fight continued and went the scheduled 12 rounds. Mayweather won by the official scores of 116-112, 117-111, and 119-109. Compubox statistics showed Mayweather as landing 188 punches to 82 for Judah.

Five days after the fight, the Nevada State Athletic Commission decided not to overturn the result of the bout, but Roger Mayweather was fined US$200,000 and suspended for one year. The suspension entails that Roger can train Mayweather, Jr. in the gym but cannot work the corner during fights. On April 17, 2006, the IBF ordered a rematch between Mayweather and Judah, but the NSAC suspended Judah for one year on May 8, 2006. Mayweather vacated the IBF title on June 20, 2006.
Mayweather rejected an offer of US$8 million to fight Antonio Margarito and split with promoter Bob Arum. De la Hoya, however, postponed his decision until 2007, leaving Mayweather in the awkward position of choosing his next opponent. Mayweather considered moving up in weight again to fight junior middleweight champion Cory Spinks, but because of negative publicity and Spinks' impending mandatory defence of his title, he finally decided to face WBC and The Ring welterweight champion Carlos Baldomir on November 4, 2006 in Las Vegas.

Mayweather would ultimately defeat Baldomir by unanimous decision for both titles. Ringside punch statistics showed Mayweather landing 199 of 458 punches, while Baldomir landed just 79 of 670. Mayweather earned $8 million for the fight, while Baldomir was paid $1.6 million. Both were career highs in earnings for each fighter at the time. During the fight, Baldomir chased Mayweather sluggishly, unable to land any meaningful shots but trying to remain the busier fighter, while Mayweather picked away with sharp jabs and hooks, even managing to cut Baldomir over his left eye in the first round. This pattern continued throughout the fight. The defensive-minded Mayweather put on what many witnesses and Mayweather himself called a "boxing clinic" to take Baldomir's WBC and Ring welterweight titles in a lopsided 12 round decision. Two judges had Mayweather winning all 12 rounds, with the other giving all but two rounds to Mayweather. After the fight Mayweather called out for a fight with Oscar De la Hoya.

Super Welterweight - De La Hoya vs Mayweather
Mayweather's next match was the long-anticipated superfight against six-division champion and current WBC Super Welterweight titleholder Oscar De La Hoya on May 5, 2007. De La Hoya's belt was on the line, which required Mayweather to move up in weight from 147 pounds to 154.
Despite De La Hoya's insistence that money was not a factor, the Mayweather-De La Hoya bout set the record for most PPV buys for a boxing match with 2.4 million households, shattering the record of 1.95 million for Evander Holyfield-Mike Tyson II. Around $120 million in revenue was generated by the PPV, which set another record. With the percentages factored in, Oscar De La Hoya ended up earning $58 million for the bout, the highest purse ever for a fighter. The previous record was $35 million, held by Tyson and Holyfield. Floyd Mayweather earned about $25 million for the fight.

At one time, Floyd Mayweather, Sr., Mayweather, Jr.'s father, was in talks to train Oscar De La Hoya and be in his corner during the fight but he decided to train with Freddie Roach. Mayweather won by split decision in 12 rounds, capturing the World Boxing Council (WBC) title.

Return to Welterweight - Fight with Ricky Hatton
Mayweather decided to relinquish his WBC junior middleweight championship and kept his WBC welterweight championship. On July 28, 2007, it was announced that Mayweather would come out of his short retirement to fight light welterweight champion Ricky Hatton which was promoted by Oscar De La Hoya's promotion company Golden Boy Promotions and Floyd Mayweather's "Mayweather Promotions." The bout was labelled "Undefeated" and took place on December 8, 2007, at the MGM Grand Garden Arena, Las Vegas, Nevada. In the build up to their fight, Mayweather claimed that he was the greatest boxer ever, saying: "I respect what Robinson and Ali did for the sport. But I am the greatest, and this is my time."

Mayweather controlled the fight from the start and knocked Hatton out in the 10th round to retain the welterweight championship. Hatton suffered a cut over his right eye in round three from the punches of Mayweather, and it seemed that it was at this point that his pace and movement began to slow. In round six Hatton lost a point for punching the back of Floyd's head as he was caught draped on the ropes. Mayweather had a huge eighth round, landing a number of clean, effective power shots.
In the 10th round Hatton was caught with a left hook thrown from Mayweather's hip, fell forward head first into the turnbuckle and hit the deck.

Hatton managed to make it to his feet, but was clearly dazed. Two more big lefts in a flurry put Ricky down again and Cortez stopped it at 1:35 of round 10.
After the fight, Mayweather said that Hatton was one of the toughest fighters he had ever fought, that he just kept coming and coming, and that he wants to promote fights, with Hatton being his first client. Mayweather announced a two-year layoff from boxing to concentrate on his promotional company.

On 18 March 2009, it was reported that Mayweather was "ready to dance again" according to a source from within the Mayweather camp. Announcing his return to the ring seemed to be somewhat of a formality at this point, as even his estranged father, current trainer of Ricky Hatton, Floyd Mayweather Sr. stated, "He's gonna fight again."

Mayweather Jr. vs. Márquez
On May 1, 2009, it was confirmed that Mayweather was coming out of a 16-month retirement to fight lightweight champion Juan Manuel Márquez at a catchweight of 144 lbs. on July 18 at the MGM Grand in Las Vegas on HBO PPV. The fight was postponed due to a rib injury Mayweather received during training. The fight took place on September 19, 2009 in conjunction with Mexican Independence Day, traditionally a big boxing weekend. During the official weigh in for their 144 lb bout, Mayweather failed to meet the required limit by weighing in at 146 lbs, four pounds heavier than Marquez. He was subsequently fined as a result. However it was later revealed that the contract was changed so that Mayweather could make weight within the welterweight limit of 140-147 lbs as long as Marquez received a large guaranteed sum of money. Mayweather won the fight by unanimous decision.

Manny Pacquiao
Pacquiao had reportedly agreed to fight Mayweather on March 13, 2010, for a split of $50 million up front, at the MGM Grand Las Vegas which the promoters of both camp already agreed. However, the fight has been called off as of now, according to promoter Bob Arum, due to disagreements about Olympic style drug tests. Floyd Mayweather's camp wanted blood tests by the United States Anti-Doping Agency, which conducts the tests anytime from the fight is signed to the fight date. However the Pacquiao camp refused to provide these samples, only willing to allow blood to be taken from Pacquiao if the test were scheduled. Freddie Roach, on the other hand, has commented that he would allow a blood sample to be taken from Pacquiao if there was a cut-off date for the blood testing or at least one week before the fight, but promoter Bob Arum has offered the chance to fight Pacquiao instead to Joshua Clottey. Leading up to and since the Clottey bout, both Arum and Roach have stated that Pacquiao would not fight under any testing that included taking blood randomly instead of the scheduled urine test.

Floyd Mayweather vs. Shane Mosley
Negotiations for a proposed matchup between Mayweather and Shane Mosley immediately began after Andre Berto pulled out of his scheduled January 30 unification bout with the latter, due to the 2010 Haiti earthquake. Both sides eventually agreed to fight on May 1, 2010 for Mosleys WBA World Welterweight title. Both Mayweather and Mosley agreed to Olympic-style testing for this bout. Mayweather won the bout by unanimous decision.







"Sugar" Shane Mosley (born September 7, 1971) from Pomona, California. He has won world titles in three weight divisions, and is the former WBA Welterweight Super Champion. He is also a major proprietor of Golden Boy Promotions.

Professional Career
Undefeated Lightweight Champion
Sugar Shane started his pro career in 1993, By 2000 he had fought 34 times amassing a 34–0 (32) record, beating undefeated Phillip Holiday to win the IBF Lightweight title. He made 9 title defences with all inside the distance, but never unified belts. Mosley relinquished his lightweight title to move up 2 divisions, facing Oscar De La Hoya for his Welterweight title.

De La Hoya vs. Sugar Shane Mosley
On June 17, 2000, Mosley met De La Hoya in Los Angeles for the WBC and IBA Welterweight titles. After twelve rounds, Mosley emerged with a split decision victory. During the fight neither man was in danger of going down, but both had badly swollen faces at the end and De La Hoya was bleeding from the nose for several rounds. Mosley earned a minimum of $15 million, while De La Hoya was guaranteed $35 million. It was later that Mosley was accused of using illegal performance enhancing drugs prior to his 2003 bout with Oscar De La Hoya. Mosley would later admit in his 2003 grand jury testimony that he used the banned drug EPO in preparation for the De la Hoya bout.

Mosley vs. Vernon Forrest I & II
He ran a successful string of defences of his Welterweight title (he vacated his title after the fight), but against three unheralded fighters. When he finally did step up his competition, it was against former Olympian Vernon Forrest. Early in the second round, the fighters clashed heads and both staggered backward as referee Steve Smoger called time. Mosley sustained a cut on the hairline. When action resumed, Forrest knocked Mosley down twice more in the round. The final scorecards read 115-110, 117-108, 118-108, in favor of Forrest.

They had a rematch six months later at Conseco Fieldhouse in Indiana, and Mosley once again lost by a unanimous decision.

Bouncing Back After Forrest
On February 8, 2003, Mosley's bout with former IBF world Light Middleweight champion Raúl Márquez ended in a no contest when Mosley accidentally head butted Marquez twice in round three, which caused two very bad cuts above the eyes of Marquez.

He and De La Hoya faced each other for the second time on September 13, this time with De La Hoya's WBC and WBA Light Middleweight belts on the line. Mosley defeated De La Hoya by a close 12 round unanimous decision, and joined the exclusive group of world boxing champions that have reigned in three or more divisions. Mosley testified in 2003 that he injected himself with the notorious doping agent EPO as he prepared for his Light Middleweight title fight against Oscar De La Hoya, according to grand jury transcripts and doping calendars.

Mosley vs. Wright I & II
On March 13, 2004, Mosley lost his WBC and WBA world Light Middleweight titles in a unification bout with IBF Jr. Middleweight champion Winky Wright, by a unanimous twelve-round decision.

On November 20, Mosley and Wright fought their rematch, and although it was scored much closer by the three judges (115-113 twice for Wright and a 114-114 tie), Mosley lost by a twelve-round majority decision.

Mosley vs Vargas I & II
On September 17, he beat another previously undefeated fighter, Jose Luis Cruz, by a ten-round decision.

Mosley then defeated Fernando Vargas on February 25, 2006 by TKO in the tenth round at the Mandalay Bay Resort and Casino, due to a massive swelling which closed Fernando's left eye. At the time of the stoppage, Mosley was winning on two scorecards 86-85, while Vargas held an 86-85 advantage on the other scorecard. A rematch was announced almost immediately.

Mosley defeated Fernando Vargas in the rematch on July 15, 2006. Mosley dominated Vargas from start to finish, eventually ending the fight via a sixth-round TKO.

Shane defeated Luis Collazo on February 11, 2007, with a unanimous decision after 12 rounds, knocking Collazo down once, to capture the WBC interim Welterweight title.

Fight With Miguel Cotto
Mosley and undefeated WBA welterweight Champion Miguel Cotto met on Nov. 10, 2007, at Madison Square Garden in a fight broadcasted on HBO Pay-Per-View. Cotto beat Mosley in a close, though unanimous decision. Soon after that match, Mosley was scheduled to face Zab Judah in a Welterweight bout in Las Vegas, Nevada on May 31. Due to an arm injury suffered by Judah, the fight was cancelled.

Mosley vs Mayorga
Mosley-Mayorga was originally scheduled for Oct. 11 at the Staples Center in Los Angeles, Golden Boy Promotions CEO Richard Schaefer and Mosley's wife and advisor, Jin Mosley, told ESPN.com.

On July 18, 2008, it was reported on ESPN.com's quick hits that The fight between Mayorga and Mosley was moved to the Home Depot Center in Carson, California and set for September 27 because of the Pavlik-Hopkins fight agreement for October 18 on HBO PPV. And the good news for fight fans was that the Mayorga-Mosley bout was not to be on HBO PPV, instead it was shown on HBO at no cost.

Shane Mosley Stopped Ricardo Mayorga with one second left in the 12th round of their junior middleweight bout, Mosley led by one point on judge Nelson Vasquez's scorecard and five on Tony Crebs' entering the 12th round. Mayorga had a one point lead on judge Pat Russell's card. The Associated Press had "Sugar" Shane Mosley ahead by three points entering the 12th.

Mosley vs Margarito
Mosley regained the WBA Welterweight "Super" championship from Antonio Margarito on January 24, 2009 at the Staples Center in Los Angeles, California. Mosley, now 37 years old, came in to the fight as a 4-1 underdog with the bookies after Margarito had spectacularly stopped Cotto 6 months earlier. Prior to the bout nobody gave Mosley a chance of prevailing- everybody believing that Margarito was too strong and that Mosley was too old. The conventional wisdom was that this was a mismatch, which would end in a brutal retirement-forcing stoppage for Sugar Shane. A comparison of their last fights- the aforementioned destruction of Cotto by Margarito and a last-gasp knockout by Mosley in a hard twelve round struggle against Mayorga- did not bode well for Sugar Shane. Some predicted a massacre. And it was - only it was Margarito that was ruthlessly clubbed about the ring, unable to land any meaningful shots.

Mosley eventually TKO'd Margarito in the ninth round, after appearing to win every round up until then, in a massive upset. Sugar Shane utterly dominated Margarito, using his superior hand speed, pinpoint accuracy and countless huge right hands to the jaw, to wear Margarito down and stop him—something that many seasoned boxing observers thought was nigh-on impossible. After knocking him down with a series of heavy overhand rights at the end of the eighth round, Margarito was unable to avoid punches during a heavy barrage from Mosley early on in the ninth, forcing the referee to step in as Margarito slumped to the canvas a second time. Margarito had never previously been stopped. It was a sensational win for Sugar Shane and propelled him back to the top of the tree in the welterweight division.

The fight was marred in a controversy after Mosley's trainer diligently spotted an illegal plaster accessory being added to Margarito's hand wraps, which had to be redone three times before the commission's officials were satisfied.

Mosley vs Mayweather
On 1st May 2010 Mosely fought undefeated pound-for-pound king Floyd Mayweather. Boxing purists had called for the fight for over ten years. On the night Mosley stunned Mayweather with two right-hand shots in the second round, nearly knocking Floyd down. Mayweather recovered well and dominated the remainder of the fight with superior hand speed, eventually winning a wide decision on the scorecards to hand Mosley only the sixth defeat of his professional career.

Steroid Use In 2003
Although Mosley has always maintained that he was unaware that steroids were involved, he was one of the athletes using the services of BALCO Labs, along with many other professional and Olympic athletes. Jeff Novitzky, a lead investigator on the BALCO case, reported that documents seized from the lab show that Mosley received "the clear" and "the cream", both designer steroids. Mosley reportedly began his doping regimen prior to his 2003 bout with Oscar De La Hoya, a match that he won due in part to his strong performance in the later rounds of the fight.

Victor Conte, the founder of BALCO, has since accused Mosley of knowingly taking performance enhancing drugs. He told the Los Angeles Times that Shane Mosley knew "exactly and precisely what he was doing" when he utilized BALCO's services. Mosley maintains that he believed the products he was using from BALCO were legal vitamins and is suing Conte for libel. In May 2008, Mosley's former trainer, Derryl Hudson, supported Conte's allegations against Mosley. In a declaration that was used in Conte's motion to have the lawsuit dismissed, Hudson wrote, "I know that Mr. Mosley was aware that the performance-enhancing drugs provided to him by Mr. Conte were banned drugs because I discussed that fact with Mr. Mosley both during and after our visit to BALCO".

In 2003, Mosley told a grand jury that he injected himself with the doping agent EPO as he prepared for a fight against Oscar De La Hoya, according to court transcripts and doping calendars reviewed by the New York Daily News. The transcript of the boxer's testimony was part of a BALCO file that was under a protective order before U.S. District Court Judge Susan Illston decided in November 2008 to allow prosecutors to share thousands of documents with Barry Bonds lawyers.